SCIENTIFICALLY PROVEN • REVOLUTIONARY
Research from Texas A&M concluded that FerAppease reduced mortality due to Bovine Respiratory Disease (BRD) by 83%¹
Overall Mortality, %
P-Value: 0.04
Steers Regain Health, %
P-Value: 0.03
One (1) FerAppease Treatment Required to Regain Health
Gain to Feed, kg/kg / pen
P-Value: 0.04
Liveweight Gain, kg/pen
P-Value: 0.04
Profit, $/pen
P-Value: 0.04
BRD Vaccine Response
P-Value: 0.04
Happy Customers
FERAPPEASE IN THE FIELD
"We're Giving Them All FerAppease."
— Dusty Williams, Owner, Athens Regional Stockyard, Athens, TN
FERAPPEASE IN THE FIELD
"Get a Calf to Eat, Get a Calf to Live."
— Glen Kirksey, DVM, Five Oaks Veterinary Practice at Athens Regional Stockyard, Athens, TN
FERAPPEASE IN THE FIELD
"The Best Product I've Ever Tried."
— Jeff Slatten, Beaver County Stockyards
FERAPPEASE IN THE FIELD
"Vet Bill Drastically Reduced."
— Clay Leisure, Beaver Feed
FERAPPEASE IN THE FIELD
"First Day Steers Cleaned the Feed Bunk!"
— Jennifer Poindexter-Runge, DVM
FERAPPEASE IN THE FIELD
"See Almost Immediate Results!"
— Barb Kaner, Tiffany Cattle Company
FERAPPEASE IN THE FIELD
"We Get More Back in Cattle Health, Cattle Value, and Cattle Growth."
— Tucker Brown, R.A. Brown Ranch
FERAPPEASE IN THE FIELD
"[Gaining] 1 lb Pays for the Whole Cost of FerAppease."
— Brock Hanel, DVM
FERAPPEASE IN THE FIELD
"54 260 lb Calves Settled, No Bawling"
— Hanel Black Simmentals, Courtland, KS
FERAPPEASE IN THE FIELD
Commingled Three Separate Pens of Bulls Together - No Riding and Fighting - No Issues!
— John McCurry, McCurry Angus Ranch, Hutchinson, KS
FERAPPEASE IN THE FIELD
"Seems like with FerAppease [Weaned Calves] Never Hit a Bad Day"
— Jeremy McBride, Manager, Wilmoth Ranch, Mount Vernon, MO
FERAPPEASE IN THE FIELD
"Overwhelmed with the Positive Response that We Were Getting from Producers"
— Ted Dahlstrom, DVM, Animal Clinic of Monett at Joplin Stockyards, Monett, MO
FERAPPEASE IN THE FIELD
"Reduction in Bawling, Reduction in Stress"
— John D. Tyra, DVM, Animal Clinic of Monett at Joplin Stockyards, Monett, MO
Shift Beef Cattle from Surviving to Thriving
Did you know that stress shifts your beef cattle's metabolism into survival mode? Stress may lead to decreasing weight gain and feed conversion and worsening health outcomes. Stress is a major obstacle keeping the beef industry from becoming a more profitable endeavor. You can overcome stress with FerAppease.
The active ingredient of FerAppease is a synthetic analogue of the Maternal Bovine Appeasing Substance (MBAS). MBAS is a naturally occurring substance that is secreted by the skin of the mammary gland of lactating animals, eliminating stress in all beef cattle treated.
Block the Stress. Face Fewer Costly Challenges!
FerAppease can and should be used every time beef cattle are exposed to management stressors, where suppression of threat perception is desirable.
COW-CALF OPERATIONS
- Weaning
- Dehorning
- Castration
- Branding
- Vaccination
STOCKERS/BACKGROUNDERS & FEEDLOTS
- Commingling
- Arrival
- Processing
- Reimplantation
- Revaccination
- Terminal Sorting
Threat Perception and FerAppease
The amygdala responds quickly to potential threats in the environment and plays a key role in determining whether environments are perceived as safe or dangerous.
Threat perception leads to activation of the hypothalamic-pituitary-adrenal (HPA) axis leading to increased release of the glucocorticoid hormone cortisol from the adrenal glands and increased release of the catecholamines epinephrine and norepinephrine.
Threat perception ultimately leads to elevated inflammation, immunosuppression, increased risk for BRD, decreased DMI, weight loss, energy inefficiency, increased morbidity and mortality.
Topically administered Maternal Bovine Appeasing Substance (MBAS) is locally assimilated by the vomeronasal organ located in the nasal cavity.
MBAS mediated stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus decreasing the perception of threat.
REDUCED THREAT PERCEPTION LEADS TO:
- Reduced flight zones
- Lower levels of Cortisol
- Lower Substance-P levels
- Lower inflammation
- Lower morbidity and mortality
Threat Perception and FerAppease
The amygdala responds quickly to potential threats in the enviornment and plays a key role in determining whether environments are perceived as safe or dangerous.
Threat perception leads to activation of the hypothalamic-pituitary-adrenal (HPA) axis leading to increased release of the glucocorticoid hormone coritsol from the adrenal glads and increased release of the catecholamines epinephrine and norepinephrine.
Threat perception ultimately leads to elevated inflammation, immunosuppression, increased risk for BRD, decreased DMI, weight loss, energy inefficiency, increased morbidity and mortality.
Topically administered Maternal Bovine Appeasing Substance (MBAS) is locally assimilated by the vomeronasal organ located in the nasal cavity.
MBAS mediated stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus decreasing the perception of threat.
REDUCED THREAT PERCEPTION LEADS TO:
- Reduced flight zones
- Lower levels of Cortisol
- Lower Substance-P levels
- Lower inflammation
- Lower morbidity and mortality
Reported Data
WEANED BEEF CALVES
"Across all the studies that we ran, we typically saw a 15-20% increase in average daily gain post-weaning in calves that received the analogue at the time of weaning."
— Dr. Reinaldo Fernandes Cooke, PhD, Department of Animal Science, Texas A&M University
BEEF CALVES
FerAppease decreased Cortisol levels 4 hours post-castration by 45.6%
BEEF CALVES
FerAppease decreased Substance-P levels 4 hours post-castration by 15.3%
FEEDLOT
"If you apply FerAppease before the stress of transport [to the feedlot], your average daily gain jumps from 20% to 30%. "
— Dr. Reinaldo Fernandes Cooke, PhD
Department of Animal Science, Texas A&M University
DIVE INTO THE DATA
1. Autumn T Pickett, Reinaldo F Cooke, Izadora S de Souza, Shea J Mackey, Administering the maternal bovine appeasing substance improves overall productivity and health in high-risk cattle during a 60-d feedlot receiving period, Journal of Animal Science, Volume 102, 2024, skae221.
2. Kelsey M Schubach, Reinaldo F Cooke, Courtney L Daigle, Alice P Brandão, Bruna Rett, Vitor S M Ferreira, Giovanna N Scatolin, Eduardo A Colombo, Genevieve M D’Souza, Ky G Pohler, Bruno I Cappellozza, Administering an appeasing substance to beef calves at weaning to optimize productive and health responses during a 42-d preconditioning program, Journal of Animal Science, Volume 98, Issue 9, September 2020, skaa269
3. Victor G L Fonseca, Bruno I Cappellozza, Osvaldo A de Sousa, Manuella Sagawa, Bruna Rett, Mário L Chizzotti, Reinaldo F Cooke, Strategic administration of an appeasing substance to improve performance and physiological responses of Bos indicus feedlot cattle, Journal of Animal Science, Volume 99, Issue 11, November 2021, skab322
4. B.I. Cappellozza, J.P. Bastos, R.F. Cooke, Short communication: Administration of an appeasing substance to Bos indicus-influenced beef cattle improves performance after weaning and carcass pH, Livestock Science, Volume 238, 2020, 104067, ISSN 1871-1413
5. Leonardo Bringhenti. (2023). Effect of FerAppease in Beef Cattle [Manuscript in preparation].
Reap the Stress-Free, Economic Benefits of Treating Your Beef Cattle with FerAppease
Prioritize your beef cattle's welfare and help them respond better to stressful events while improving your profitability. Place your order today!
PRESS MENTIONS
FAQs
What is FerAppease?
The active ingredient of FerAppease is a synthetic analogue of the Maternal Bovine Appeasing Substance (MBAS). MBAS is naturally secreted by the sebaceous gland located on the skin of the mammary gland with the unique function of inducing an appeasing effect on the nursing offspring.
FerAppease is topically applied, and the active ingredient (MBAS) is assimilated by the vomeronasal gland located in the nose of the animals. The MBAS stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus, dramatically decreasing threat perception and its downstream stress consequences.
How do you apply FerAppease?
FerAppease is for use only in healthy cattle by topical administration behind the poll and to the skin above the muzzle.
When can FerAppease be used?
FerAppease can and should be used every time animals are exposed to management and physiological stressors where suppression of threat perception is desirable. i.e. weaning, dehorning, castration, branding, transportation, commingling, vaccination, parturition, interruption of lactation (dry off), breeding, et al.
What is the dosage of FerAppease on Cattle?
> 200 lb: Apply 5 mL of FerAppease behind the poll and a second 5 mL application to the skin above the muzzle.
< 200 lb: Apply 2.5 mL of FerAppease behind the poll and a second 2.5 mL application to the skin above the muzzle.
How long before FerAppease takes effect?
Behavior modulation and stress mitigation starts to take place immediately after FerAppease is applied.
Is a prescription required for FerAppease?
No, FerAppease does not require a veterinarian's prescription or a Veterinary Feed Directive plan.
How much does FerAppease cost per dose?
> 200 lb - 10 mL dose: $3.00/ head
< 200 lb - 5 mL dose: $1.50/ head
Are there any side effects of FerAppease?
There are no known side effects.
Is there a withdrawal period after using FerAppease?
No, there is no withdrawal period after using FerAppease.
Can FerAppease be applied when it’s raining?
FerAppease is an oil-based product. It is recommended to apply FerAppease on a dry animal. It is best to allow FerAppease at least 30 minutes to absorb into the skin of the animal before getting wet.
What is the duration of each application?
FerAppease is effective for a period of 14 days. Most economically relevant, stressful events have a duration of less than 14 days. Therefore, a single application will get the animals through the entire challenge period.
Is there a benefit to reapplying FerAppease after the 14-day period?
If an animal is being run through the chute after the 14-day period for any reason such as revaccinating, studies have shown there are benefits to reapplication at this time.
Does FerAppease expire?
FerAppease has a two-year shelf life.
How should FerAppease be stored?
Store at controlled room temperature at 10 - 30℃ (50-86℉). Do not refrigerate or freeze.
Where can FerAppease be purchased?
FerAppease is available for purchase in feed stores, veterinary clinics, through your MWI/AHI representatives or on our website.
What is a p-value?
A p-value is a statistical measure used to determine the significance of results in a hypothesis test. It indicates the probability of obtaining the observed results if the null hypothesis (no effect or difference) is true. A low p-value (≤ 0.05) suggests rejecting the null hypothesis in favor of the alternative hypothesis (indicating an effect or difference), while a high p-value (> 0.05) suggests retaining the null hypothesis.
Can I request the full study data for FerAppease?
Yes, please email inquiry@feraah.com.
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