SCIENTIFICALLY PROVEN • REVOLUTIONARY
Improve your bottom line and cut your losses short with FerAppease for healthier, heavier, high performing beef calves.
Featured Review
FERAPPEASE IN THE FIELD
"The Best Product I've Ever Tried."
— Jeff Slatten, Beaver County Stockyards
Happy Customers
FERAPPEASE IN THE FIELD
"Vet Bill Drastically Reduced."
— Clay Leisure, Beaver Feed
FERAPPEASE IN THE FIELD
"First Day Steers Cleaned the Feed Bunk!"
— Jennifer Poindexter-Runge, DVM
FERAPPEASE IN THE FIELD
"See Almost Immediate Results!"
— Barb Kaner, Tiffany Cattle Company
Shift Beef Calves from Surviving to Thriving
Did you know that stress shifts your beef calves' metabolism into survival mode, decreasing weight gain and feed conversion and worsening health outcomes? Stress is a major obstacle keeping the beef industry from becoming a more profitable endeavor. You can overcome this obstacle with FerAppease.
The active ingredient of FerAppease is a synthetic analogue of the Maternal Bovine Appeasing Substance (MBAS). MBAS is a naturally occurring substance that is secreted by the skin of the mammary gland of lactating animals, eliminating stress in all beef cattle treated.
Block the Stress. Face Fewer Costly Challenges!
FerAppease can and should be used every time beef cattle are exposed to management stressors, where suppression of threat perception is desirable.
COW-CALF OPERATIONS
- Weaning
- Dehorning
- Castration
- Branding
- Vaccination
STOCKERS/BACKGROUNDERS & FEEDLOTS
- Commingling
- Arrival
- Processing
- Reimplantation
- Revaccination
- Terminal Sorting
Threat Perception and FerAppease
The amygdala responds quickly to potential threats in the environment and plays a key role in determining whether environments are perceived as safe or dangerous.
Threat perception leads to activation of the hypothalamic-pituitary-adrenal (HPA) axis leading to increased release of the glucocorticoid hormone cortisol from the adrenal glands and increased release of the catecholamines epinephrine and norepinephrine.
Threat perception ultimately leads to elevated inflammation, immunosuppression, increased risk for BRD, decreased DMI, weight loss, energy inefficiency, increased morbidity and mortality.
Topically administered Maternal Bovine Appeasing Substance (MBAS) is locally assimilated by the vomeronasal organ located in the nasal cavity.
MBAS mediated stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus decreasing the perception of threat.
REDUCED THREAT PERCEPTION LEADS TO:
- Reduced flight zones
- Lower levels of Cortisol
- Lower Substance-P levels
- Lower inflammation
- Lower morbidity and mortality
- Increased weight gain
- Increased feed efficiency
Threat Perception and FerAppease
The amygdala responds quickly to potential threats in the enviornment and plays a key role in determining whether environments are perceived as safe or dangerous.
Threat perception leads to activation of the hypothalamic-pituitary-adrenal (HPA) axis leading to increased release of the glucocorticoid hormone coritsol from the adrenal glads and increased release of the catecholamines epinephrine and norepinephrine.
Threat perception ultimately leads to elevated inflammation, immunosuppression, increased risk for BRD, decreased DMI, weight loss, energy inefficiency, increased morbidity and mortality.
Topically administered Maternal Bovine Appeasing Substance (MBAS) is locally assimilated by the vomeronasal organ located in the nasal cavity.
MBAS mediated stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus decreasing the perception of threat.
REDUCED THREAT PERCEPTION LEADS TO:
- Reduced flight zones
- Lower levels of Cortisol
- Lower Substance-P levels
- Lower inflammation
- Lower morbidity and mortality
- Increased weight gain
- Increased feed efficiency
Scientific Data
WEANED BEEF CALVES
FerAppease increased weight gain 45-days post-weaning by 36lbs
"Across all the studies that we ran, we typically saw a 15-20% increase in average daily gain post-weaning in calves that received the analog at the time of weaning."
— Dr. Reinaldo Fernandes Cooke, PhD
Department of Animal Science, Texas A&M University
WEANED BEEF CALVES
FerAppease treated calves drive a ROI of 31.8x
BEEF CALVES
FerAppease decreased Cortisol levels 4 hours post-castration by 45.6%
BEEF CALVES
FerAppease decreased Substance-P levels 4 hours post-castration by 15.3%
BEEF CALVES
FerAppease increased weight gain 17 days post-castration by 15.8%
FEEDLOT
"If you apply FerAppease before the stress of transport [to the feedlot], your average daily gain jumps from 20% to 30%. "
— Dr. Reinaldo Fernandes Cooke, PhD
Department of Animal Science, Texas A&M University
FEEDLOT STEERS
FerAppease treated steers at feedlot arrival increased weight gain at the end of the feeding period by 32lbs
FEEDLOT STEERS
FerAppease improved feed efficiency by 47g/kg
REFERENCES
1. Kelsey M Schubach, Reinaldo F Cooke, Courtney L Daigle, Alice P Brandão, Bruna Rett, Vitor S M Ferreira, Giovanna N Scatolin, Eduardo A Colombo, Genevieve M D’Souza, Ky G Pohler, Bruno I Cappellozza, Administering an appeasing substance to beef calves at weaning to optimize productive and health responses during a 42-d preconditioning program, Journal of Animal Science, Volume 98, Issue 9, September 2020, skaa269
2. Victor G L Fonseca, Bruno I Cappellozza, Osvaldo A de Sousa, Manuella Sagawa, Bruna Rett, Mário L Chizzotti, Reinaldo F Cooke, Strategic administration of an appeasing substance to improve performance and physiological responses of Bos indicus feedlot cattle, Journal of Animal Science, Volume 99, Issue 11, November 2021, skab322
3. B.I. Cappellozza, J.P. Bastos, R.F. Cooke, Short communication: Administration of an appeasing substance to Bos indicus-influenced beef cattle improves performance after weaning and carcass pH, Livestock Science, Volume 238, 2020, 104067, ISSN 1871-1413
4. Leonardo Bringhenti. (2023). Effect of FerAppease in Beef Cattle [Manuscript in preparation].
Reap the Stress-Free, Economic Benefits of Treating Your Beef Calves with FerAppease
Help your beef calves respond better to stressful events, stay healthier and get heavier, while improving your profitability. Place your order today!
PRESS MENTIONS
FAQs
What is FerAppease?
The active ingredient of FerAppease is a synthetic analogue of the Maternal Bovine Appeasing Substance (MBAS). MBAS is naturally secreted by the sebaceous gland located on the skin of the mammary gland with the unique function of inducing an appeasing effect on the nursing offspring.
FerAppease is topically applied, and the active ingredient (MBAS) is assimilated by the vomeronasal gland located in the nose of the animals. The MBAS stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus, dramatically decreasing threat perception and its downstream stress consequences.
How is FerAppease applied?
FerAppease is for use only in healthy cattle by topical administration to the nuchal skin and the skin above the muzzle.
For adult animals > 200lbs: Apply 5ml of FerAppease to the nuchal skin and a second 5 ml application to the skin above the muzzle.
For youngstock < 200lbs: Apply 2.5ml of FerAppease to the nuchal skin and a second 2.5 ml application to the skin above the muzzle.
How long before FerAppease takes effect?
Behavior modulation and stress mitigation starts to take place immediately after FerAppease is applied. For weaned calves, bellowing and walking around the fence is minimized starting 24 hours after the product is applied. Feed behavior is also stimulated 12 hours from the time the product is applied.
Do I need a prescription for FerAppease?
No, FerAppease does not require a veterinarian's prescription or a Veterinary Feed Directive plan. There are also no meat withholding requirements.
Can I request the full study data for FerAppease?
Yes, please email inquiry@feraah.com.
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